Stem cell‐based cell therapy for Huntington disease: A review
Identifieur interne : 000C68 ( Main/Exploration ); précédent : 000C67; suivant : 000C69Stem cell‐based cell therapy for Huntington disease: A review
Auteurs : Manho Kim ; Soon-Tae Lee ; Kon Chu ; Seung U. Kim [Canada]Source :
- Neuropathology [ 0919-6544 ] ; 2008-02.
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Abstract
Huntington disease (HD) is a devastating neurodegenerative disorder and no proven medical therapy is currently available to mitigate its clinical manifestations. Although fetal neural transplantation has been tried in both preclinical and clinical investigations, the efficacy is not satisfactory. With the recent explosive progress of stem cell biology, application of stem cell‐based therapy in HD is an exciting prospect. Three kinds of stem cells, embryonic stem cells, bone marrow mesenchymal stem cells and neural stem cells, have previously been utilized in cell therapy in animal models of neurological disorders. However, neural stem cells were preferably used by investigators in experimental HD studies, since they have a clear capacity to become neurons or glial cells after intracerebral or intravenous transplantation, and they induce functional recovery. In this review, we summarize the current state of cell therapy utilizing stem cells in experimental HD animal models, and discuss the future considerations for developing new therapeutic strategies using neural stem cells.
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DOI: 10.1111/j.1440-1789.2007.00858.x
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Kim</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:229F12C2C01674694E867419F1457EAC253121E4</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1111/j.1440-1789.2007.00858.x</idno><idno type="url">https://api.istex.fr/document/229F12C2C01674694E867419F1457EAC253121E4/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002370</idno><idno type="wicri:Area/Main/Curation">002046</idno><idno type="wicri:Area/Main/Exploration">000C68</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Stem cell‐based cell therapy for Huntington disease: A review</title><author><name sortKey="Kim, Manho" sort="Kim, Manho" uniqKey="Kim M" first="Manho" last="Kim">Manho Kim</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Lee, Soon Ae" sort="Lee, Soon Ae" uniqKey="Lee S" first="Soon-Tae" last="Lee">Soon-Tae Lee</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Chu, Kon" sort="Chu, Kon" uniqKey="Chu K" first="Kon" last="Chu">Kon Chu</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Kim, Seung U" sort="Kim, Seung U" uniqKey="Kim S" first="Seung U." last="Kim">Seung U. Kim</name><affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology, UBC Hospital, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Neuropathology</title><idno type="ISSN">0919-6544</idno><idno type="eISSN">1440-1789</idno><imprint><publisher>Blackwell Publishing Asia</publisher><pubPlace>Melbourne, Australia</pubPlace><date type="published" when="2008-02">2008-02</date><biblScope unit="volume">28</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="1">1</biblScope><biblScope unit="page" to="9">9</biblScope></imprint><idno type="ISSN">0919-6544</idno></series><idno type="istex">229F12C2C01674694E867419F1457EAC253121E4</idno><idno type="DOI">10.1111/j.1440-1789.2007.00858.x</idno><idno type="ArticleID">NEUP858</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0919-6544</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Huntington disease</term><term>functional recovery</term><term>mesenchymal stem cell</term><term>neural stem cell</term><term>neurotrophic factors</term><term>transplantation</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Huntington disease (HD) is a devastating neurodegenerative disorder and no proven medical therapy is currently available to mitigate its clinical manifestations. Although fetal neural transplantation has been tried in both preclinical and clinical investigations, the efficacy is not satisfactory. With the recent explosive progress of stem cell biology, application of stem cell‐based therapy in HD is an exciting prospect. Three kinds of stem cells, embryonic stem cells, bone marrow mesenchymal stem cells and neural stem cells, have previously been utilized in cell therapy in animal models of neurological disorders. However, neural stem cells were preferably used by investigators in experimental HD studies, since they have a clear capacity to become neurons or glial cells after intracerebral or intravenous transplantation, and they induce functional recovery. In this review, we summarize the current state of cell therapy utilizing stem cells in experimental HD animal models, and discuss the future considerations for developing new therapeutic strategies using neural stem cells.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Chu, Kon" sort="Chu, Kon" uniqKey="Chu K" first="Kon" last="Chu">Kon Chu</name><name sortKey="Kim, Manho" sort="Kim, Manho" uniqKey="Kim M" first="Manho" last="Kim">Manho Kim</name><name sortKey="Lee, Soon Ae" sort="Lee, Soon Ae" uniqKey="Lee S" first="Soon-Tae" last="Lee">Soon-Tae Lee</name></noCountry><country name="Canada"><noRegion><name sortKey="Kim, Seung U" sort="Kim, Seung U" uniqKey="Kim S" first="Seung U." last="Kim">Seung U. Kim</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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